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Publications

Lawson K, Nho Y, Stewart R, Wu S, Cole EF, Herrera D, Chisolm S, et al. A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis. JID Innovations. 2026;100470.

Yu X, Huang Y, Patil MJ, Xing Y, Ru F, Kawamoto R, Han L, Undem BJ, et al. MrgprC11 expression and function in vagal afferent nerves in the esophagus. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2026;330(3).

Wu S, Steele H, Lawson K, Stewart R, Han L. Assessment of pruritogen-induced responses in the glabrous skin of mice. Molecular Pain. 2026;22:17448069261420554.

Xing Y, Nho Y, Lawson K, Zhu Y, Ellison A, Chang M, Hancock W, Han L. MrgprC11+ Jugular Neurons Control Airway Hyperresponsiveness in Allergic Airway Inflammation. Am J Respir Cell Mol Biol. 2025 April. 

Osuoji C, DeGrazia T, Cole E, Lawson K, Hilley H, Xing Y, Han L, Chisolm S, Yan X, Sun Y, Liu Y, Chen SC, Feldman RJ. Exploring Pruritus in Bullous Pemphigoid: Analysis of Quality-of-Life Metrics and Potential Biological Mechanisms. J Invest Dermatol Innovations. 2025 March. 

Jiang H, Cui H, Chen M, Li F, Shen X, Guo CJ, Hoekel GE, Zhu Y, Han L, Wu K, Holtzman MJ, Liu Q. Divergent sensory pathways of sneezing and coughing. Cell. 2024 Oct 17. 

Xing Y, Nho Y, Lawson K, Steele H, Han L. Regional Differences in Itch Transmission. J Invest Dermatol. 2024 Nov. 

Feng J, Zhao Y, Xie Z, Zang K, Sviben S, Hu X, Fitzpatrick JAJ, Wen L, Liu Y, Wang T, Lawson K, Liu Q, Yan Y, Dong X, Han L, Wu GF, Kim BS, Hu H. Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle. Sci Transl Med. 2022 Jul. 

Nho Y, Lawson K, Banovic F, Han L. Staphylococcus aureus phenol-soluble modulins induce itch sensation. J Dermatol Sci. 2022 Jul;107(1):48-51. 

Steele H, Xing Y, Zhu Y, Hilley H, Lawson K, Nho Y, Niehoff T, Han L*. MrgprC11+ sensory neurons mediate glabrous skin itch. PNAS. 2021;118(15). (Reported by Georgia Tech Research Horizons, Science Daily, MedicalResearch.com, Neuroscience News, and more than 15 other websites.)

Xing Y, Steele H, Hilley H, Zhu Y, Niehoff T, Lawson K, Han L*. Visualizing the itch-sensing skin arbors. Journal of Investigative Dermatology. 2021 May;141(5):1308-1316.

Steele H, Han L*. The signaling pathway and polymorphisms of Mrgprs. Neuroscience Letters. 2020;744:135562.

Xing Y, Chen J, Hilley H, Steele H, Yang J, Han L*. Molecular signature of pruriceptive MrgprA3+ neurons. Journal of Investigative Dermatology. 2020;140(10):2041-2050. 

Han L*, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X*. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness. Nature Neuroscience. 2018 Mar;21(3):324-328. *Corresponding authors. (Reported by ScienceDaily, Hopkins Medicine, ScienceNewsline, and many others.)

Zhu Y, Hanson CE, Liu Q, Han L*. Mrgprs activation is required for chronic itch conditions in mice. Itch. 2017;2(3). 

Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. PNAS. 2017;114(10).

Zaccone EJ, Lieu T, Muroi Y, Potenzieri C, Undem BE, Gao P, Han L, Canning BJ, Undem BJ. Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways. PLoS One. 2016;11(5).

Chang AY, Mann TS, McFawn PK, Han L, Dong X, Henry PJ. Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways. Respiratory Research. 2016;17(1):62.

McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015;519(7542):237-241.

Han L*, Dong X*. Itch mechanisms and circuits. Annu Rev Biophys. 2014;43:331-355. *Corresponding authors.

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience. 2013;16(2):174-182. (Reported by The New York Times, NBC News, FOX News, The Baltimore Sun, Huffington Post, Daily Mail, Science Daily, Scientific American, and many others.)

Kim YS, Chu Y, Han L, Li M, Li Z, LaVinka PC, Sun S, Tang Z, Park K, Caterina MJ, Ren K, Dubner R, Wei F, Dong X. Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron. 2014;81(4):873-887.

Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain. 2014;155(8):1613-1621.

Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain. 2014;137(Pt 4):1039-1050.

He SQ, Han L, Li Z, Xu Q, Tiwari V, Yang F, Guan X, Wang Y, Raja SN, Dong X, Guan Y. Temporal changes in MrgC expression after spinal nerve injury. Neuroscience. 2014;261:43-51.

He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. Pain. 2014;155(3):534-544.

Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X. Mechanisms of itch evoked by beta-alanine. J Neuroscience. 2012;32(42):14532-14537.

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